Whiteboard Chemistry with Joe White

Nanoparticles

Chemistry-only: surface-area-to-volume ratio, the scale of nanoparticles, and how their properties and uses differ from the same material in bulk.

AQA Specification Paper 1

NanoparticlesT

📖 Definition

Nanoparticle — a particle with a diameter in the range of 1–100 nm (nanometres). 1 nm = 1 × 10⁻⁹ m. Nanoparticles are only slightly larger than individual atoms and molecules.

Nanoscience — the study of nanoparticles and how they can be used.

ScaleTypical size
Atom~0.1 nm = 1 × 10⁻¹⁰ m
Small molecule~0.5–2 nm
Nanoparticle1–100 nm = 1 × 10⁻⁹ – 1 × 10⁻⁷ m
Fine particles (PM2.5)100–2 500 nm (1 × 10⁻⁷ – 2.5 × 10⁻⁶ m)
Coarse particles (PM10) — dust2 500–10 000 nm (2.5 × 10⁻⁶ – 1 × 10⁻⁵ m)
Human hair~70 000 nm (70 µm)
The scale of small things SI PREFIXES · EACH STEP DOWN = 10× SMALLER (A LOG SCALE) ▲ BIGGER ▼ SMALLER 10³ 10² 10¹ 10⁰ 10⁻¹ 10⁻² 10⁻³ 10⁻⁴ 10⁻⁵ 10⁻⁶ 10⁻⁷ 10⁻⁸ 10⁻⁹ 10⁻¹⁰ KILO km BASE UNIT metre (m) DECI dm CENTI cm MILLI mm MICRO µm NANO nm ×1000 ×1000 ×1000 About ten football pitches ≈ 1 km = 1000 m A metre ruler ≈ 1 m Width of your hand ≈ 10 cm = 0.1 m Width of a fingernail ≈ 1 cm = 0.01 m A grain of sand ≈ 1 mm = 0.001 m Width of a human hair ≈ 70 µm = 0.07 mm A human cell ≈ 10–30 µm A bacterium ≈ 1–2 µm = 1000–2000 nm A virus ≈ 100 nm = 0.1 µm NANOPARTICLE 1–100 nm — the focus of this topic A single atom ≈ 0.1 nm = 1×10⁻¹⁰ m Everyday Living things Nanoscale Atoms

The SI prefixes on a logarithmic scale of size — each step down is ten times smaller.

Surface Area to Volume Ratio

As a particle gets smaller, its surface area to volume ratio increases dramatically. A nanoparticle has a very large surface area relative to its volume, compared to the same material as a large lump. For a cube, every time the side length decreases by a factor of 10, the surface area to volume ratio increases by a factor of 10.

✅ Why this matters

Chemical reactions happen at surfaces. A nanoparticle exposes a much greater proportion of its atoms at the surface than a larger particle made of the same material. More surface atoms = more reaction sites = reactions happen much faster.

This is why nanoparticles are so effective as catalysts — a tiny mass of nanoparticles can catalyse a reaction that would need far more of the same material in bulk form.

Changed Properties

Nanoparticles can have very different properties from the same material in bulk (large-scale) form. This is mainly because of their very high surface area to volume ratio. Examples:

  • Gold nanoparticles appear red or purple rather than gold, depending on their size.
  • Titanium dioxide nanoparticles are transparent (unlike bulk TiO2, which is white) — used in sun creams.
  • Some materials become much more reactive, stronger, or conductive at the nanoscale.

Beyond the syllabus (useful context): you are not required to recall these specific materials or their individual properties — only the general principle that a high surface-area-to-volume ratio can give nanoparticles different properties, together with the application areas named below.

Uses of Nanoparticles

ApplicationMaterialReason nanoparticles are used
Sun creamsTitanium dioxide (TiO2)Absorbs UV radiation. Nanoparticles are transparent on skin (unlike bulk TiO2 which is white and opaque).
CatalystsVarious metals (e.g. platinum)Very high surface area dramatically increases the rate of reaction.
Medical drug deliveryVariousNanoparticles can cross cell membranes and deliver drugs directly to target cells (e.g. cancer cells). Buckminster fullerene can store medicines in its hollow centre.
Electronics / sensorsCarbon nanotubes, grapheneTiny size enables microscale circuitry; high conductivity; sensitive detection of small amounts of substances.
Stronger materialsCarbon nanotubesIncredibly strong and lightweight — reinforcing composites for sports equipment and aerospace.
DeodorantsSilver nanoparticlesSilver nanoparticles are antibacterial; they kill bacteria on the skin that cause body odour. The high surface area makes them effective at low concentrations.
Other antibacterial productsSilver nanoparticlesSilver is antibacterial; nanoparticles increase the surface area in contact with bacteria — used in wound dressings, socks, and food packaging.

Risks of Nanoparticles

The use of nanoparticles raises concerns because little is yet known about their long-term effects on human health and the environment. Scientists treat nanoparticles cautiously because:

  • Their very small size means they can penetrate cell membranes and potentially damage cells from the inside.
  • Some nanoparticles may be toxic to living organisms.
  • Very small particles might cross the blood-brain barrier, potentially affecting the nervous system.
  • If released into the environment, nanoparticles could act as nanopollutants, with unpredictable effects on ecosystems.
  • They can speed up biological reactions in unpredictable ways.
⚠️ Common pitfall — balance benefits and risks

AQA questions on nanoparticles often ask you to evaluate their use. Always acknowledge both the benefits and the risks. A complete answer mentions the high surface area to volume ratio (benefit: faster reactions / more effective catalysts), and acknowledges that their long-term health and environmental effects are not yet fully understood (risk). Avoid writing as though nanoparticles are either entirely safe or entirely dangerous.

🧪 Exam-style questions
Q1 [1 mark]

What is the approximate number of atoms in a nanoparticle?Tick (✓) one box.

Q2 [1 mark]

Nanoparticles of some elements can be used as catalysts. Which element is most likely to be used as a catalyst?Use the periodic table. Tick (✓) one box.

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